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RESEARCH ARTICLE |
a Division on Aging, Harvard Medical School, and the Gerontology Division, Department of Medicine, Beth Israel Deaconess Medical Center, Boston, Massachusetts
Margery H. Silver, New England Centenarian Study, Beth Israel Deaconess Medical Center, 330 Brookline Avenue, Palmer 108, Boston, MA 02215 E-mail: margery_silver{at}hms.harvard.edu.
Decision Editor: Toni C. Antonucci, PhD
The New England Centenarian Study is a population-based study of all centenarians in 8 towns near Boston, MA. Age was confirmed for 43 centenarians all alive on a designated date. To determine prevalence of dementia in centenarians, the authors analyzed neuropsychological, medical, and functional status data for 34 (79%) of the centenarians. Definition of dementia was based on the Consortium to Establish a Registry for Alzheimer's Disease criteria, and a Clinical Dementia Rating (CDR) score was formulated for each participant. Seven (21%) had no dementia (CDR score 0), and an additional 4 (12%) were assigned a CDR score of 0.5, uncertain or deferred diagnosis. The remaining 22 (64%) had at least some degree of dementia. The authors calculated Barthel Index scores to determine ability to perform activities of daily living. There was a statistically significant correlation between CDR scores and Barthel Index scores (r = -0.73). Correlation was strongest for those with no or severe dementia, with the greatest range of function measured among those with moderate dementia.
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